Applied genomic in cerebrovascular disease


  • Hugo Sánchez Hernández Universidad de Quintana Roo
  • Alma Ortiz-Plata National Institute of Neurology and Neurosurgery Manuel Velasco Suárez. Mexico.
  • Iris Nava Jiménez Universidad de Quintana Roo
  • Fidel Hernández-Hernández National Institute of Neurology and Neurosurgery Manuel Velasco Suárez. Mexico.



Cerebrovascular disease involve the alterations caused by pathology process of the sanguineous vessels, affecting one or many brain areas. Cerebrovascular disease is also known like stroke or ictus; it is the third cause of death around the world and is the neurologic pathology with the most prevalence rate. Cerebrovascular disease induces several changes in genetic expression inside the neurovascular unit (glia cells, neurons and ependymal cells); principally, changes in the oxidative stress and calcium inflow into the cells, this could start cellular death and tissue destruction, causing an irreversible injury in brain, losing several functions. The injury causes the activation of signaling pathways to respond to the stress, where many molecules such as proteins and mRNA are involved to act as intermediaries to activate or deactivate stress me- chanisms; these molecules are able to transmit extracellular signals into the nucleus activating early gene expression like proto-oncogenes and several transcription factors to repair the cerebral injury. It is important to know the relation of the changes in genetic expression and proteins to avoid the development of injury and to activate the brain recovery. This knowledge let us diagnose the injury rate and propose therapeutic mechanisms to reduce or avoid the adverse effects on time, before the cellular death start.



Cómo citar

Sánchez Hernández, H., Ortiz-Plata, A., Nava Jiménez, I., & Hernández-Hernández, F. (2019). Applied genomic in cerebrovascular disease. Revista Científica Salud Uninorte, 34(3).



Artículo de Revisión