Potential Joint Effect of the SNP rs3749474T and SNP rs4864548AAlleles of the CLOCK Gene on Nutritional Status and Chronotype in Young University Students

Authors

DOI:

https://doi.org/10.14482/sun.37.1.613.2

Keywords:

CLOCK gene, obesity, chronotype

Abstract

Objective: To compare the nutritional status, chronotype and eating behavior of a subject who simultaneously has the rs3749474T and rs4864548A polymorphisms to groups of subjects who have only one of these polymorphisms.

Methods: The presence of the polymorphisms was established by PCR. BMI, cardiovascular risk, and fat percentage were determined as described by Durnin and Womersley and the Siri equation. The TFEQ-P19 questionnaire (adapted to the Chilean population) and the Horne-Ostberg questionnaire were applied.

Results: The subject with both polymorphisms presented obesity, cardiovascular risk, and late-night chronotype. Its scores on the dimensions of uncontrolled feeding and emotional feeding were low, and its score for cognitive restriction was the highest.

Conclusions: The presence of the TA haplotype (rs3749474; rs4864548A) would increase the possibility of having a late-night type chronotype, risk of obesity, and cardiovascular risk associated with waist centimeters.

Author Biographies

  • Carolina Pino-astorga, Facultad de Salud. Escuela de Nutrición y Dietética. Universidad Bernardo O´Higgins. Santiago, Chile.

    Facultad de Ciencias de la Salud, Escuela de Nutrición y Dietética, Universidad Bernardo O´Higgins. Santiago (Chile)

  • Angel gerardo Roco-Videla, Universidad Católica de la Santísima Concepción, Concepción Chile.Universidad Bernardo O'Higgins, Chile

    Facultad de Ciencias de la Salud, Programa Magíster en Ciencias químico-biológicas, Universidad Bernardo O´Higgins. Santiago (Chile).
    Facultad de Ingeniería, Universidad Católica de la Santísima Concepción. Concepción (Chile)

  • Macarena Valladares Vega, Departamento de Ciencias Química y Biológicas Facultad de Salud, Universidad Bernardo O´Higgins, Chile

    Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O´Higgins. Santiago (Chile).

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Published

2022-01-19

Issue

Section

ORIGINAL ARTICLE

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