Esta es un versión antigua publicada el 2023-06-30. Consulte la versión más reciente.

Effect of pesticides on cognitive and motor performance in habitants of rural areas of Tolima

Autores/as

  • Katherine Prado-Guzmán Universidad de Ibagué
  • Diana Ximena Puerta-Cortés Universidad de Ibagué
  • José Luis Poveda-Cuellar Universidade Federal de Viçosa

Palabras clave:

Neuropsychology, pesticides, cognitive and motor performance, rural areas

Resumen

Organophosphate pesticides can cause cognitive impairment. However, the farmer uses different pesticides in all phases of the same crop. The aim of this study was to analyze the effect of serial pesticides on cognitive and motor performance in samples of exposed, indirectly exposed, and unexposed people. In the exploratory study with a cross-sectional design, a total of 135 small farmers from the informal sector participated. Mini-Mental, Trail Making, Rey-Osterrieth Complex Figure, Digit Retention, Hopkins Verbal Learning and the Grooved Pegboard tests were administered. The results show that the highest serial exposure occurs with Glyphosate, Lorsban, Furadan and Paraquat. The group with direct exposure to pesticides presented a lower performance in working memory, explicit verbal memory, constructive praxis and fine motor control of the right hand, than the indirectly exposed group and the unexposed group. In conclusion, direct and serial exposure to pesticides generates neuropsychological and motor impairment in informal sector farmers, it is recommended the development of public politics that promote healthy and safe practices, to minimize the risks due to the use of these substances.

Biografía del autor/a

Katherine Prado-Guzmán, Universidad de Ibagué

Docente Programa de Psicología. Investigadora del Grupo Educación, Salud y Sociedad. Universidad de Ibagué

Diana Ximena Puerta-Cortés, Universidad de Ibagué

Doctora en Psicología, magister en psicología con énfasis en adicciones y violencia. Psicóloga. Experta en psicología de la salud y adicciones. Docente de tiempo completo Universidad de Ibagué. Directora del grupo de investigación "Educación, Salud y Sociedad" GESS y coordinadora del semillero NeuroTech.

José Luis Poveda-Cuellar, Universidade Federal de Viçosa

Biólogo magister. Investigador del  Laboratório Sistemática Molecular "Beagle", Departamento de Biologia Animal. Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brasil

Citas

Abubakar, Y., Tijjani,H., Egbuna, C., Adetunji, C. O., & Patrick-Iwuanyanwu, K. C. (2020). Pesticides, History, and Classification. Natural Remedies for Pest, Disease and Weed Control, 29-42.https://doi.org/10.1016/B978-0-12-819304-4.00003-8

Anger, W.K., Farahat, F.M., Lein, P.J., Lasarev, M.R., Olson, J.R., Farahat, T. M., & Rohlman, D.S. (2020). Magnitude of Behavioral Deficits Varies with Job-Related Chlorpyrifos Exposure Levels among Egyptian Pesticide Workers. Neurotoxicology, 77, 216-230. https://doi:10.1016/j.neuro.2020.01.012

Agostini, L.P., Dettogni, R.S., dos Reis, R.S., Stur, E., dos Santos, E.V.W., Ventorim, D. P., García, F. M., Cardoso, R, C., Graceli, J. B., & Louro, I. D. (2020). Effects of glyphosate exposure on human health: Insights from epidemiological and in vitro studies. Science of The Total Environment, 705, 135808. https://doi:10.1016/j.scitotenv.2019.135808

Agronet. (2020). Estadísticas agropecuarias.https://www.agronet.gov.co/estadistica/Paginas/home.aspx

Ardila, A. & Roselli, M. (2019). Neuropsicología Clínica. Manual Moderno.https://colombia.manualmoderno.com/catalogo/neuropsicologia-clinica-9786074488074-9786074488135.html

Arango, J.C. & Rivera, D. (2015). Neuropsicología en Colombia: Datos normativos, estado actual y retos a futuro. Manizales: U. Autónoma de Manizales.https://editorial.autonoma.edu.co/index.php/libros/catalog/book/35

Berent, S., Giordani, B., Albers, J.W., Garabrant, D.H., Cohen, S.S., Garrison, R.P., & Richardson, R.J. (2014). Effects of occupational exposure to chlorpyrifos on neuropsychological function: A prospective longitudinal study. NeuroToxicology, 41, 44–53. https://doi.org/10.1016/j.neuro.2013.12.010

Berrigan, L., Fisk, J., Walker, L., Wojtowicz, M., Rees, L., Freedman, M., & Marrie R. (2014). Reliability of regression-based normative data for the oral symbol digit modalities test: an evaluation of demographic influences, construct validity, and impairment classification rates in multiple sclerosis samples. The Clinical Neuropsychologist, 28(2):281-299. https://doi:10.1080/13854046.2013.871337

Blanc-Lapierre, A., Bouvier, G., Gruber, A., Leffondré, K., Lebailly, P., Fabrigoule C., & Baldi, I. (2013). Cognitive Disorders and Occupational Exposure to Organophosphates: Results From the PHYTONER Study. American Journal of Epidemiology, 177(10), 1086–1096. https://doi:10.1093/aje/kws346

Blesa, R. (2001). Clinical Validity of the "Mini-Mental State" for spanish speaking communities. Neuropsychologia, 1150-1157. https://doi.org/10.1016/S0028-3932(01)00055-0

Chase Bailey, K., Soble, J., Bain, K., & Fullen, C. (2018). Pruebas de validez de desempeño integradas en la Prueba de aprendizaje verbal de Hopkins —Revisada y Prueba breve de memoria visuoespacial —Revisada: Un estudio de replicación. Archives of Clinical Neuropsychology, 33(7), 895–900. https://doi.org/10.1093/arclin/acx111

Corral, S.A., De Angel, V., Salas, N., Zúñiga-Venegas, L., Gaspar, P.A., & Pancetti, F. (2017). Cognitive impairment in agricultural workers and nearby residents exposed to pesticides in the Coquimbo Region of Chile. Neurotoxicology and Teratology, 62, 13-19. https://doi:10.1016/j.ntt.2017.05.003

Dassanayake, T., Weerasinghe, V., Gawarammana, I. & Buckley, N. (2021). Subacute and chronic neuropsychological sequalae of acute organophosphate pesticide self-poisoning: a prospective cohort study from Sri Lanka. Clinical Toxicology, 59:2, 118-130. https://doi.org/10.1080/15563650.2020.1778719

Diaz-Santos, M., Suarez, P., Marquine, M., Rivera, M., Artiola i Fortuny L., Heaton, R. & Cherner, M. (2019). Updated Demographically Adjusted Norms for the Brief Visuospatial Memory Test-Revised and Hopkins Verbal Learning Test-Revised in Monolingual Spanish Speakers from the United States –Mexico Border Region. rchives of Clinical Neuropsychology, 34(7), 1250. https://doi.org/10.1093/arclin/acz029.17

Drane D., Yuspeh, R., Huthwaite, J. & Klingler, L. (2002). Demographic characteristics and normative observations for derived-trail making test indices. Neuropsychiatry, neuropsychology, and behavioral neurology, 15(1), 39-43.https://pubmed.ncbi.nlm.nih.gov/11877550/

Farahat, T., Abdelrasoul, G., Amr, M., Shebl, M., Farahat, F., & Ange, W. (2003). Neurobehaviouraleffects among workers occupationally exposed to organophosphorous pesticides. Occupational and Environmental Medicine, 60, 279-286.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1740510/

Federal Insecticide, Fungicide, and Rodenticide Act. (2019). Pesticides and Public Health. Recuperado de https://www.epa.gov/pesticides/pesticides-and-public-health

Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician". Journal of psychiatric research, 12(13), 189–198.https://doi.org/10.1016/0022-3956(75)90026-6

Harris, J., Echemendía, R., Ardila, A., & Rosselli, M. (2001). Cross-Cultural Cognitive and Neuropsychological Assessment. Handbook of Psychoeducational Assessment, 391-414.https://www.sciencedirect.com/book/9780120585700/handbook-of-psychoeducational-assessment

Hernández, J., Contreras, E., & Zuluaga, S. (2008). Intoxicación por paraquat: descripción de un caso clínico. Acta toxicológica argentina, 16 (1), 5-8. http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432008000100002

Ismail, A.A., Bonner, M.R., Hendy, O., Rasoul, G.A., Wang, K., Olson, J.R., Rohlman, D.S., (2017). Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt. PloSOne,12, 1–13. https://doi.org/10.1371/journal. pone.0172696

Ismail, Z., Rajji, T. K. , & Schulman, K. I. (2009). Brief cognitive screening instruments: An update. International Journal of Geriatric Psychiatry, 25(2), 111–120. https://doi.org/10.1002/gps.2306

Ismail, A.A., Wang, K., Olson, J.R., Bonner, M.R., Hendy, O., Rasoul, G. A., & Rohlman, D.S. (2017). The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators. Journal of Toxicology and Environmental Health, 80(10-12), 542-555. https://doi:10.1080/15287394.2017.1362612

Jamal, F., Quazi, S., Haque, Q.S., Singh, S., (2016). Interrelation of glycemic status and neuropsychiatric disturbances in farmers with organophosphorus pesticide toxicity. Open Biochemistry Journal,10, 27–34.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041135/

Jiménez, D., Delerce, S., Dorado, H., Cock, J., Muñoz, L.A., Agamez, A., & Jarvis, A. (2019). Ascalable scheme to implement data-driven agriculture for small-scale farmers. Global Food Security, 23, 256-266. https://doi:10.1016/j.gfs.2019.08.004

Jiménez-Quintero, C.A., Pantoja-Estrada, A., & Leonel H.F. (2016). Riesgos en la salud de agricultores por uso y manejo de plaguicidas, microcuenca “la pila”. Revista Universidad y Salud, 18(3), 417-431. http://dx.doi.org/10.22267/rus.161803.48

Kamel, F., & Hoppin, J.A. (2004). Association of pesticide exposure with neurologic dys-function and disease. Environmental Health Perspectives, 112(9), 950-958. https://doi:10.1289/ehp.7135

Khan, K., Ismail, A.A., Abdel Rasoul, G., Bonner, M.R., Lasarev, M.R., Hendy, O., Al-Batanony, M., Crane, A.L., Singleton, S.T., Olson, J. R., & Rohlman, D.S. (2014). Longitudinal assessment of chlorpyrifos exposure and self-reported neurological symptoms in adolescent pesticide applicators. BMJ Open, 4(3), e004177. https://doi:10.1136/bmjopen-2013-004177

Jokanovi?, M. (2018). Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review Milan ToxicologyToxicology.410,125-131.https://doi.org/10.1016/j.tox.2018.09.009

Lezak, M., Howieson, D., & Loring, D. (2004). Neuropsychological assessment. Oxford University Press.https://global.oup.com/academic/product/neuropsychological-assessment-9780195395525?cc=us&lang=en&

López, K., Pinedo, C., & Zambrano, M. (2015). Prácticas de Salud Ocupacional y niveles de biomarcadores séricos en aplicadores de plaguicidas de cultivos de arroz en Natagaima-Tolima, Colombia. Revista de Toxicología, 32(2), 102-106. https://www.redalyc.org/pdf/919/91942717005.pdf

Mackenzie Ross, S.J., Brewin, C.R., Curran, H.V., Furlong, C.E., Abraham-Smith, K.M., & Harrison, V. (2010). Neuropsychological and psychiatric functioning in sheepfarmers exposed to low levels of organophosphate pesticides.Neurotoxicology and Teratology, 32(4), 452–459. https://doi:10.1016/j.ntt.2010.03.004

Malekirad, A.A., Faghih, M., Mirabdollahi, M., Kiani, M., Fathi, A., & Abdollahi, M. (2013). Neurocognitive, mental health, and glucose disorders in farmers exposed to organophosphorus pesticides. Archives of Industrial Hygiene and Toxicology, 64(1), 1–8. https://badge.dimensions.ai/details/doi/10.2478/10004-1254-64-2013-2296?domain=https://sciendo.com

Mehrabi, Z., Jiménez, D., & Jarvis, A. (2018). Democratize access to digital agronomy Nature, 555.https://www.cheric.org/research/tech/periodicals/view.php?seq=1631625

Merker, B., Podell, K., & Wingate, M. (2017). Grooved Pegboard Test. In: Kreutzer J., DeLucaJ., Caplan B. (eds). Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://link.springer.com/referenceworkentry/10.1007%2F978-0-387-79948-3_187

Meyer-Baron, M., Knapp, G., Schäper, M., & van Thriel, C. (2015). Meta-analysis on occupational exposure to pesticides –Neurobehavioral impact and dose–response relationships. Environmental Research, 136, 234–245. https://doi:10.1016/j.envres.2014.09.030

Myrberg, K., Hydén, L. & Samuelsson, C. (2020). The mini-mental state examination (MMSE) from a language perspective: an analysis of test interaction. Clinical Linguistics & Phonetics, 34(7), 652-670. https://doi:10.1080/02699206.2019.1687757

Muñoz-Quezada, M.T., Lucero, B., Iglesias, V., Muñoz, M.P., Achú, E., Cornejo, C., Concha, C., Grillo, A., & Brito, A.M. (2016). Plaguicidas organofosforados y efecto neuropsicológico y motor en la Región del Maule, Chile. Gaceta Sanitaria, 30(3), 227–231.https://dx.doi.org/10.1016/j.gaceta.2016.01.006

Naughton, S. X., & Terry, A.V. (2018). Neurotoxicity in acute and repeated organophosphate exposure. Toxicology, 408, 101-112. https://doi:10.1016/j.tox.2018.08.011Norton, R. D. (2017). Cap 10 Colombia: Crop Competitiveness by Region Evaluated via Tracks 1 and 2. The Competitiveness of Tropical Agriculture A Guide to Competitive Potential with Case Studies. Academic Press: Estados Unidos.https://www.elsevier.com/books/the-competitiveness-of-tropical-agriculture/norton/978-0-12-805312-6

Ramírez-Botero, A., & Pachajoa, H. (2016). Syndromic microphthalmia-3 caused by a mutation on gene SOX2 in a Colombian male patient. Congenital Anomalies, 56, 250–252. https://doi.org/10.1111/cga.12170

Rey, A. (1941). L’examen psychologique dans les cas d’encéphalopathie traumatique. Archives of Psychology, 28, 286-340. https://psycnet.apa.org/record/1943-03814-001

Roldan-Tapia, L., Nieto-Escamez, F.A., del Aguila, E.M., Laynez, F., Parron, T., & Sanchez-Santed, F. (2006). Neuropsychological Sequelae From Acute Poisoning and Long-Term Exposure to Carbamate and Organophosphate Pesticides. Neurotoxicology and Teratology,28(6), 694-703. https://doi:10.1016/j.ntt.2006.07.004

Roldán-Tapia, L., Parrón, T., & Sánchez-Santed, F. (2005). Neuropsychological Effects of Long-Term Exposure to Organophosphate Pesticides. Neurotoxicology and Teratology, 27(2), 259-66. https://doi:10.1016/j.ntt.2004.12.002

Rosselli, D., Ardila, A., Pradilla, G., Morillo, L., Bautista, L., Rey, O., & Camacho, M. (2000). El examen mental abreviado, Mini-Mental State Examination, como prueba de selección para el diagnóstico de demencia: estudio poblacional colombiano. Revista de Neurología, 30 (5), 428-432. https://doi.org/10.33588/rn.3005.99125Ross, S.M., McManus, I.C., Harrison, V., & Mason, O. (2012). Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review. Critical Reviews in Toxicology, 43(1), 21–44. https://doi:10.3109/10408444.2012.738645

Rothlein, J., Rohlman, D., Lasarev, M., Phillips, J., Muniz, J., & McCauley, L. (2006). Organophosphate pesticide exposure and neurobehavioral performance in agricultural and nonagricultural Hispanic workers. Environmental Health Perspectives, 114(5), 691–6. https://doi.org/10.1289/ehp.8182

Sankoh, A.I., Whittle, R., Semple, K.T., Jones, K.C., & Sweetman, A.J. (2016). An assessment of the impacts of pesticide use on the environment and health of rice farmers in Sierra Leone. Environment International, 94, 458-466. https://doi:10.1016/j.envint.2016.05.034

Starks, S.E., Gerr, F., Kamel, F., Lynch, C.F., Jones, M.P., Alavanja, M. C., Sandler, E. P., & Hoppin, J.A. (2012). Neurobehavioral function and organophosphate insecticide use among pesticide applicators in the Agricultural Health Study. Neurotoxicology and Teratology, 34(1), 168-176. https://doi:10.1016/j.ntt.2011.08.014

Taghavian, F., Vaezi, G., Abdollahi, M., Malekirad, A.A., 2016. A comparative study of the quality of life, depression, anxiety and stress in farmers exposed to organophosphate pesticides with those in a control group. Journal of Chemical Health Risks,6 (2), 143–151.http://www.jchr.org/article_544139.html

Varona, M., Henao, G., Lancheros, A., Murcia, A., Díaz, S., & de Segurado, P. (2017). Factores de exposición a plaguicidas organofosforados y carbamatos en el departamento del Putumayo.Biomédica, 27(3), 400-409.https://doi:10.7705/biomedica.v27i3.202

Varona, M., Idrovo, A. J. (2016). Determinantes sociales de la intoxicación por plaguicidas entre cultivadores de arroz en Colombia. Revista de Salud Pública, 18 (4), 617. https://doi.org/10.15446/rsap.v18n4.5261

Wechsler, D. (2012). Escala de inteligencia de Wechsler para adultos IV (WAIS-IV). Pearson.

Zhang, H. Y., Wang, C., & Li, H. S. (2021). Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi. Chinese journal of industrial hygiene and occupational diseases, 39(4), 313–316. https://journals.indexcopernicus.com/search/details?id=36151

Zyoud, S. H. (2018). Investigating global trends in paraquat intoxication research from 1962 to 2015 using bibliometric analysis. American Journal of Industrial Medicine, 61(6), 462-470. https://doi:10.1002/ajim.22835

Descargas

Publicado

2022-10-03 — Actualizado el 2023-06-30

Versiones