Effect of temperature in bursting of thalamic reticular cells

Autores/as

  • Oscar Emilio Hernández Bustos Universidad del Norte
  • Eduardo E Zurek Uninorte
  • David Vera Universidad del Norte
  • Alfonso Cepeda-Emiliani Universidad del Norte

DOI:

https://doi.org/10.14482/sun.34.1.9736

Resumen

Objective: To show the relation between the four parameters associated to bursting discharges of the thalamic reticular cells (TRNn): the maximum firing frequency (fmax) and the temperature at which it occurs (Tfmax), the range of temperatures defined as the full width at half maximum (?Th) and the maximum specific low threshold calcium conductance (GT).

Materials and Methods: In order to simulate the TRNn bursting activity a computational simulation model was implemented using the NEURON software, which incorporates morphological and electrophysiological data and stimuli properties closely related to reality.

Results: It was found that there are nonlinear relations between the parameters. The fmax frequency follows a quadratic grow with temperature and tends asymptotically towards a limit value with the maximum calcium conductance.  In the same manner, ?Th increases until reaching a limit value as function of fmax and GT. However, the increment per frequency unit is bigger than the increment per conductance unit.

Conclusions: There were obtained four equations that model the relations between the parameters associated to bursting discharges of the TRNn in rats and other neurons with similar characteristics in different animal species.

Biografía del autor/a

Oscar Emilio Hernández Bustos, Universidad del Norte

Licenciado en Matemáticas y Física, Especialista en Física General, Magíster en Biofísica Médica

Eduardo E Zurek, Uninorte

Departamento de ingeniería de sistemas, Universidad del Norte, km 5 vía a Puerto Colombia, Barranquilla,Colombia.

David Vera, Universidad del Norte

Departamento de Ciencias Naturales y exactas, Universidad de la Costa, Calle 58 N° 55-66, Barranquilla,Colombia.

Alfonso Cepeda-Emiliani, Universidad del Norte

Departamento de Medicina, Universidad del Norte, km 5 vía a Puerto Colombia, Barranquilla, Colombia.

Publicado

2017-12-07

Cómo citar

Hernández Bustos, O. E., Zurek, E. E., Vera, D., & Cepeda-Emiliani, A. (2017). Effect of temperature in bursting of thalamic reticular cells. Revista Científica Salud Uninorte, 34(1). https://doi.org/10.14482/sun.34.1.9736

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Artículo Original