Effect of temperature in bursting of thalamic reticular cells

Authors

  • Oscar Emilio Hernández Bustos Universidad del Norte
  • Eduardo E Zurek Uninorte
  • David Vera Universidad del Norte
  • Alfonso Cepeda-Emiliani Universidad del Norte

DOI:

https://doi.org/10.14482/sun.34.1.9736

Abstract

Objective: To show the relation between the four parameters associated to bursting discharges of the thalamic reticular cells (TRNn): the maximum firing frequency (fmax) and the temperature at which it occurs (Tfmax), the range of temperatures defined as the full width at half maximum (?Th) and the maximum specific low threshold calcium conductance (GT).

Materials and Methods: In order to simulate the TRNn bursting activity a computational simulation model was implemented using the NEURON software, which incorporates morphological and electrophysiological data and stimuli properties closely related to reality.

Results: It was found that there are nonlinear relations between the parameters. The fmax frequency follows a quadratic grow with temperature and tends asymptotically towards a limit value with the maximum calcium conductance.  In the same manner, ?Th increases until reaching a limit value as function of fmax and GT. However, the increment per frequency unit is bigger than the increment per conductance unit.

Conclusions: There were obtained four equations that model the relations between the parameters associated to bursting discharges of the TRNn in rats and other neurons with similar characteristics in different animal species.

Author Biographies

  • Oscar Emilio Hernández Bustos, Universidad del Norte
    Licenciado en Matemáticas y Física, Especialista en Física General, Magíster en Biofísica Médica
  • Eduardo E Zurek, Uninorte
    Departamento de ingeniería de sistemas, Universidad del Norte, km 5 vía a Puerto Colombia, Barranquilla,Colombia.
  • David Vera, Universidad del Norte
    Departamento de Ciencias Naturales y exactas, Universidad de la Costa, Calle 58 N° 55-66, Barranquilla,Colombia.
  • Alfonso Cepeda-Emiliani, Universidad del Norte
    Departamento de Medicina, Universidad del Norte, km 5 vía a Puerto Colombia, Barranquilla, Colombia.

Published

2017-12-07

Issue

Section

ORIGINAL ARTICLE

How to Cite

Effect of temperature in bursting of thalamic reticular cells. (2017). SCIENTIFIC JOURNAL SALUD UNINORTE, 34(1). https://doi.org/10.14482/sun.34.1.9736