Early-Onset High-Risk Multiple Myeloma: A Case Report from Bogotá (Colombia)

Authors

  • Santiago Gomez Jordan Universidad del Norte, Colombia
  • Santiago Escalante Perez Universidad Pontificia Bolivariana, Colombia
  • Olga Paola Omaña Clinica Del Country, Colombia

DOI:

https://doi.org/10.14482/sun.41.02.922.618

Keywords:

Multiple myeloma, anemia, young adult, cytogenetics, case report

Abstract

Multiple myeloma (MM) is characterized by plasma cell overgrowth, typically affecting older individuals. However, it is exceptionally rare in young adults, accounting for only 2.2% of cases in those under 40. A 35-year-old female patient with recent-onset anemia requiring transfusion presented with gingival bleeding and ecchymosis. She presented severe anemia with no thrombocytopenia, elevated creatinine, and vertebral (T10 and T11) fractures. Electrophoresis revealed a monoclonal peak, bone marrow aspiration showed 80% infiltration by lambda plasma cells and cytogenetic studies identified t(4;14). Treatment included induction therapy with 4 cycles of bortezomib, lenalidomide, dexamethasone (VRd protocol) consolidation with daratumumab-VRd, and planned autologous transplantation. This case highlights the challenges and importance of diagnosing MM in young adults. Cytogenetic abnormalities, such as t(4;14) play a role in influencing prognosis and guiding treatment decisions. Thus, understanding the interplay between young age and cytogenetics is vital in this disease.

Author Biographies

Published

2025-06-13

Issue

Section

CLINICAL CASE REPORTS

How to Cite

Early-Onset High-Risk Multiple Myeloma: A Case Report from Bogotá (Colombia). (2025). SCIENTIFIC JOURNAL SALUD UNINORTE, 41(2), 696-705. https://doi.org/10.14482/sun.41.02.922.618

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