Antibiotic Resistance: Origins, evolution and healthcare-associated infections

Authors

  • María Inés Torres-Caycedo Universidad de Boyacá
  • Lisbeth Teresa Castro-Gutiérrez Universidad de Boyacá
  • Carlos Fernando Prada-Quiroga Universidad de Boyacá
  • Diana Paola López Velandia Docente- Investigadora Grupo de Investigación de Bacteriología y Laboratorio Clìnico Universidad de Boyacá Tunja- Boyacá- Colombia

DOI:

https://doi.org/10.14482/sun.34.2.615.32%20

Keywords:

Resistencia Microbiana a Medicamentos, Genes Bacterianos, infección, Transferencia Genética Horizontal, Historia

Abstract

The increased incidences of Healthcare-associated Infections (HAI) caused by multidrug-resistant bacteria, have led to an enlarged number of morbidity and mortality cases. Besides, other factors that are affected are patients, families and institutions providing health services. Therefore, the permanent study of the subject is necessary to identify possible strategies that contribute to the reduction of the issue. A critical review of the literature based on the origin of antibiotics, the evolution of their respective resistance, and the impact on public health; from a historical and current perspective. The search of the literature was carried out in the bibliographic databases: Pubmed, Web of Science, Scopus, SciELO, The Cochrane Library and Lilacs. The reviewed literature showed, from the historical viewpoint, the discovery of antibiotics to the last-generation antibiotics. The rapid coevolution of genes for antibiotics resistance and its subsequent spread to hundreds of species of microorganisms by Horizontal Transfer gene (HTG). It is also discussed how the expansion in antimicrobial resistance (AMR) generates a series of factors that increase health-care associated infections care (HAI) and their impact on public health. The development of antibiotics from the discovery to recent changes in the behavior and response of the microorganisms with the generation of AMR shortly after, is one of the most fantastic examples of the evolution that exists in nature.

Author Biography

Diana Paola López Velandia, Docente- Investigadora Grupo de Investigación de Bacteriología y Laboratorio Clìnico Universidad de Boyacá Tunja- Boyacá- Colombia

Bacterióloga y Laboratorista Clínica, Universidad de Boyacá, Investigadora Grupo de investigación de Bacteriología y Laboratorio Clínico

Published

2018-01-31

How to Cite

Torres-Caycedo, M. I., Castro-Gutiérrez, L. T., Prada-Quiroga, C. F., & López Velandia, D. P. (2018). Antibiotic Resistance: Origins, evolution and healthcare-associated infections. Salud Uninorte, 34(2). https://doi.org/10.14482/sun.34.2.615.32

Issue

Section

Review Article

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