Influence of acute and chronic cocaine administration, evaluation of abstinence and retention of long-term drug effects on emotional behavior of the mouse.
Keywords:
Abuso de drogas, cocaína efectos fisiológicos, Psicología experimental, Drug abuse, cocaine-physiological effects, experimental psychologyAbstract
The effects of the administration of (0.1, 1.0, and 10.0 mg/kg) doses of cocaine hydrochlorate at severe and chronic levels were evaluated upon the emotional conduct in mice using two models: "box with holes" and "x-shaped labyrinth." Additionally, the effects produced by the absence of the drug were also evaluated, and subsequently the permanence of such effects in a long-term period were also evaluated within a group of 60 male mice from CDM strain that were randomly assigned to four different groups. For the first study project, one experimental scheme and one control scheme were designed; for the second study project, an experimental scheme was implemented with three experimental groups and one control group that managed the same doses. In the first study project, all participants were subjected to only one dose of drug or saline sol. randomly assigned, and a log on each subject's conduct was made 30 minutes after such dose was administered in the second experiment -drug administration at a chronic level- all subjects were injected the drug once a day during six consecutive days, and 30 minutes after the sixth dose was administered, a log on the subjects' conduct was made. Seven days after the last administration was carried out another log on each subject's conduct to observe if the last log on each subject's conduct was presented to each one, to evaluate the permanency of the long-term pharmacological effects. The data were analyzed by means of the Analysis of Variance of one way for the comparison among the groups, and later on the Tukey test to see which the groups of the significant differences were. Additionally, for the comparison between the acute and chronic administration in each one of the models, the t Student was used. It was found that the dose 0.1 mg/kg produces the so much bigger differential effects in the acute administration as in the chronic one. The doses 1.0 and 10.0 mg/mg didn’t present substantial differences in the two administration forms. The results show that the acute administration of the cocaine hydrochIorate is ansiogenic, and the chronic administration is ansiolitic. Changes were neither observed in the emotional behavior related with me abstinence, nor it was long-term permanency of pharmacological effects.
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