High-Grade Urothelial Carcinoma with Thyroid Metastasis: A Case of Tumor-to-Tumor Metastasis

Authors

  • Luisana Molina Pimienta Instituto Nacional de Cancerología, Colombia
  • María Paola Gonzáles Orjuela Instituto Nacional de Cancerología, Colombia
  • Alfredo Romero Rojas Instituto Nacional de Cancerología, Colombia
  • Ricardo Bruges Maya Instituto Nacional de Cancerología, Colombia

DOI:

https://doi.org/10.14482/sun.42.02.925.001

Keywords:

Transitional Cell Carcinoma, Metastasis, Thyroid, Papillary Carcinoma

Abstract

Introduction: Metastases to the thyroid gland are rare, representing less than 3% of malignant
tumors in this gland. Also, metastases from urothelial carcinomas to papillary thyroid carcinoma
are extremely rare.
Objective: To present an uncommon case and its clinical approach.
Materials and methods: An exhaustive review of the patient’s electronic medical history was conducted
in the National Cancer Institute SAP system, along with an analysis of histology slides and
immunohistochemistry studies.
Results: A patient with high-grade urothelial carcinoma in the right renal pelvis and bladder, initially
managed with surgery. The patient later developed local and pulmonary recurrence, alongside
the appearance of thyroid nodules. Following the initiation of platinum-based chemotherapy was initiated, and during maintenance with immunotherapy, a total thyroidectomy was performed. Pathological
evaluation revealed high-grade urothelial carcinoma metastasis within a papillary thyroid
carcinoma.
Conclusion: Urothelial carcinoma is an uncommon donor tumor in tumor-to-tumor metastasis
cases. This case meets the established criteria for this condition, demonstrating the coexistence of
more than one primary tumor, where the recipient tumor is an authentic neoplasm and the donor
tumor represents a true metastasis exhibiting growth within the recipient tumor.

Author Biographies

  • Luisana Molina Pimienta, Instituto Nacional de Cancerología, Colombia

    Médica cirujana. Médica internista. Especialista en Oncología Clínica. Instituto
    Nacional de Cancerología, Bogotá (Colombia). lsmolinap@unbosque.edu.co.
    https://orcid.org/0000-0001-5505-9710

  • María Paola Gonzáles Orjuela, Instituto Nacional de Cancerología, Colombia

    Médica. Especialista en Epidemiología. Hospitalaria, Unidad de Oncología Clínica,
    Instituto Nacional de Cancerología, Bogotá (Colombia). mpaolagonzalezo@hotmail.com. https://orcid.org/0009-0007-9370-454X

  • Alfredo Romero Rojas, Instituto Nacional de Cancerología, Colombia

    Médico. Especialista en Patología. Médico patólogo, Instituto Nacional de Cancerología,
    Bogotá (Colombia). aromero@cancer.gov.co. https://orcid.org/0000-0003-0650-5731

  • Ricardo Bruges Maya , Instituto Nacional de Cancerología, Colombia

    Médico cirujano. Especialista en Medicina Interna. Especialista en Oncología.
    Oncólogo clínico, Instituto Nacional de Cancerología, Bogotá (Colombia).
    rbruges@cancer.gov.co. https://orcid.org/0000-0002-3649-9515

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Published

2026-07-09

Issue

Section

CLINICAL CASE REPORTS

How to Cite

High-Grade Urothelial Carcinoma with Thyroid Metastasis: A Case of Tumor-to-Tumor Metastasis. (2026). SCIENTIFIC JOURNAL SALUD UNINORTE, 42(2), 574-583. https://doi.org/10.14482/sun.42.02.925.001

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