Caffeine (150 Mg Kg) and spatial learning in mice (Acquisition and Retention)
Abstract
Caffeine was evaluated (150mg/kg) for its effect on spatial learning (acquisition and retention) in mice, by means of the out latency, speed, successes, returns, errors and excrements in a labyrinth of 3 x 3 meters. Subjects were modeled for a route in the labyrinth, then 20 males and 20 females were randomized for caffeine and saline solution (s.e.) administration during eight days. Then the retention of this learning was observed and a new route was modeled to evaluate their retention 24 hours later: Caffeine incremented retention of learning 1 measured by the largest number of successes; for the second route, females with caffeine exhibited bigger speed and successes; on the other hand males, presented less successes and speed than all the groups; As a result we can say that caffeine strengthened the retention of learning 2 in females and it weakened it in males. As a conclusion then, caffeine (150mg/kg) positively influenced spatial learning retention in females, but not its acquisition.
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