Gingival overgrowth induced by orthodontic treatment: histological and immunohistochemical analysis of two clinical cases

Authors

  • Victor Hugo Simancas Escorcia Universidad del Sinú, Cartagena, Colombia
  • Jesús Martínez-Vargas Universidad de Cartagena, Colombia
  • Maryi Pacheco-Ramírez Universidad de Cartagena, Colombia
  • Antonio Díaz-Caballero Universidad de Cartagena, Colombia

DOI:

https://doi.org/10.14482/sun.39.01.247.822

Keywords:

Orthodontics, Gingival overgrowth, Ki-67 Antigen, Cell Proliferation, Collagen

Abstract

Orthodontic treatment-induce gingival overgrowth (OTGO) is uncontrolled growth of the gingiva. Here, we report two clinical cases of systemically healthy male patients with generalized GH undergoing orthodontic treatment, with and without association with dental biofilm. In both patients, hyperplastic epithelial tissue was identified with abundant Ki-67 positive cells and connective tissue rich in randomly distributed collagen fibers. Future studies will be useful to elucidate the pathophysiological differences of OTGO with and without relation to dental biofilm.

Author Biographies

Victor Hugo Simancas Escorcia, Universidad del Sinú, Cartagena, Colombia

Ph.D. en Fisiología y Patología. Grupo de Investigación GENOMA. Facultad de Ciencias de la Salud, Universidad del Sinú - Cartagena, Colombia. https://orcid.org/0000-0003-0910-030X https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001197274. victor.simancas@unisinu.edu.co

Jesús Martínez-Vargas, Universidad de Cartagena, Colombia

Semillerista Grupo interdisciplinario de investigaciones y tratamientos odontológicos Universidad de Cartagena (GITOUC). Cartagena, Colombia. https://orcid.org/0000-0002-6747-1670. jmartinezv4@unicartagena.edu.co

Maryi Pacheco-Ramírez, Universidad de Cartagena, Colombia

Especialista en Ortodoncia, Universidad de Cartagena, Colombia.
https://orcid.org/0000-0001-9496-1838. maryi_pach@hotmail.com

Antonio Díaz-Caballero, Universidad de Cartagena, Colombia

Ph.D. en Ciencias Biomédicas. Grupo GITOUC. Universidad de Cartagena,Colombia. https://orcid.org/0000-0001-9693-2969 Correo: adiazc1@unicartagena.edu.co https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000273350

Published

2023-06-15

How to Cite

Simancas Escorcia, V. H., Martínez-Vargas, J. ., Pacheco-Ramírez, M. ., & Díaz-Caballero, A. . (2023). Gingival overgrowth induced by orthodontic treatment: histological and immunohistochemical analysis of two clinical cases. Salud Uninorte, 39(1). https://doi.org/10.14482/sun.39.01.247.822

Issue

Section

Clinic Case

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