Retrospective analysis of microbiological profile and antimicrobial resistance in pediatric urinary infection from public hospitals in Quito-Ecuador

Authors

  • Ivonne Mendieta-Tello Pontificia Universidad Católica del Ecuador
  • Adriana Arnao-Noboa Pontificia Universidad Católica del Ecuador
  • Diana Calderón-Robalino Pontificia Universidad Católica del Ecuador
  • Enrique Gea-Izquierdo Pontificia Universidad Católica del Ecuador

DOI:

https://doi.org/10.14482/sun.39.01.614.589

Keywords:

Escherichia coli,, antibiotic, susceptibility and resistance, malformation

Abstract

Objective: Determine the microbiological profile and antimicrobial susceptibility in urinary infection in children, and the use of effective medicines. Materials and methods: Descriptive, cross-sectional, observational, and multicenter study. 445 urine cultures and the results of antibiograms were studied in three public hospitals in Quito (Ecuador). In relation to the causal agents, absolute frequencies and proportions were established. In the bivariate analysis, Chi-squared test (p < 0.05) and PR [CI 95 %; p < 0.05] was applied between history of kidney or urinary tract malformation and risk of infection. Results: There was evidence of resistance to aminopenicillins of 73.5%, ampicillin plus sulbactam 31.8 %, trimethoprim-sulfamethoxazole 55.5 %, first and second generation cephalosporins up to 33%, resistance to third and fourth generation cephalosporins from 21.3 to 47%. In relation to urinary malformation and the isolate of a bacteria different from Escherichia coli, Klebsiella pneumoniae PR 2,66 [CI 95 %, 1.9-3.6; p < 0.05] and Pseudomonas aeruginosa PR 2.07 [CI 95 %, 1.2-3.5; p < 0.05] were identified. Conclusions: In our locality it wouldn’t be appropriate to start antibiotic treatment with aminopenicillins, trimethoprim-sulfamethoxazole or first to fourth generation cephalosporins in urinary tract infection due to their resistance. The presence of urinary malformation is associated with infection by bacteria other than Escherichia coli.

Author Biographies

Ivonne Mendieta-Tello, Pontificia Universidad Católica del Ecuador

Médica. Especialista en Pediatría, Pontificia Universidad Católica del Ecuador. Postgrado
de Pediatría, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Orcid: https://orcid.org/0000-0003-4579-7044. 
ivonnekmendieta@hotmail.com

Adriana Arnao-Noboa, Pontificia Universidad Católica del Ecuador

Médica. Especialista en Pediatría, Universidad Internacional del Ecuador. Especialista
en Infectología Pediátrica, Universidad Nacional Autónoma de México. Hospital
Vozandes, Hospital Metropolitano, Hospital de los Valles, Quito, Ecuador. Pontificia
Universidad Católica del Ecuador, Facultad de Medicina, Quito, Ecuador.
Orcid: https://orcid.org/0000-0002-3926-3049.
Correo: adri_arnao@yahoo.com

Diana Calderón-Robalino, Pontificia Universidad Católica del Ecuador

Médica. Especialista en Pediatría, Pontificia Universidad Católica del Ecuador. Postgrado
de Pediatría, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Orcid: https://orcid.org/0000-0002-6388-7345.
Correo: dia_marc@hotmail.com

Enrique Gea-Izquierdo, Pontificia Universidad Católica del Ecuador

Ph.D. Epidemiología, Universidad Complutense de Madrid. Ph.D. Salud Pública, Universidad
de Málaga. MPH, Universidad de Granada. Pontificia Universidad Católica del Ecuador, Facultad de Medicina, Quito, Ecuador. Universidad Rey Juan Carlos, Medicina
Preventiva y Salud Pública, Madrid, España. Programa María Zambrano, Unión Europea-España.
Orcid: https://orcid.org/0000-0002-7123-6251. Correo: enriquegea@yahoo.es

Published

2023-06-15

How to Cite

Mendieta-Tello, I., Arnao-Noboa, A., Calderón-Robalino, D., & Gea-Izquierdo, E. (2023). Retrospective analysis of microbiological profile and antimicrobial resistance in pediatric urinary infection from public hospitals in Quito-Ecuador. Salud Uninorte, 39(1). https://doi.org/10.14482/sun.39.01.614.589

Issue

Section

Original Article