Relationship of herpes simplex virus and stage IV periodontitis: A systematic review of the literature

Authors

  • Martha Leonor Rebolledo-Cobos Universidad Metropolitana, Colombia
  • Fernando Viaña Bermúdez Universidad Metropolitana, Colombia
  • Lucy Erazo-Coronado Universidad Libre, Colombia
  • Ana María Erazo Coronado Universidad Metropolitana, Colombia
  • Miurika Ramos-Llanes Universidad Metropolitana, Colombia
  • Diana Contreras-Nieto Universidad Metropolitana, Colombia

DOI:

https://doi.org/10.14482/sun.40.01.620.112

Keywords:

Chronic Periodontitis, Stage IV, Herpes Simplex, antibiotics, antiviral

Abstract

Objective: The purpose of this study is to determine, through a systematic review of the literature, the relationship between the Herpes Simplex Virus (HSV) and stage IV periodontitis to guide therapeutics for the treatment of this entity. Methodology: The method was a systematic review of the literature in PubMed, Elsevier, Science Direct and Scielo databases, using the PRISMA checklist. Systematic review documentation and meta-analysis about experimental study designs, molecular biology studies, and in vivo studies on the relationship between herpes simplex virus type 1 and stage IV periodontitis, published between 2017 and 2022, in Spanish and English were obtained in a search conducted between April 8 and 22, 2022. Three articles were eligible after applying the inclusion and exclusion criteria, out of an initial total of 1.797. Results: The reviewed articles show a more consistent relationship of the human herpes virus, increased by its presence and association with advanced stage periodontal disease, such as stage IV periodontitis, compared to healthy patients and patients with gingivitis. Conclusion: Pharmacological management as adjuvant of periodontal therapy in patients with stage IV periodontitis, accompanied by antibiotic and antiviral therapy, can reduce or eliminate herpes simplex in sites with periodontal disease.

 

Author Biographies

Martha Leonor Rebolledo-Cobos, Universidad Metropolitana, Colombia

Profesor asociado Universidad Metropolitana, Barranquilla (Colombia). https://orcid.org/0000-0002-0488-2464. mrebolledo@unimetro.edu.co

Fernando Viaña Bermúdez, Universidad Metropolitana, Colombia

Profesor asociado Universidad Metropolitana, Barranquilla (Colombia). https://orcid.org/0000-0003-0795-0343. fviana@unimetro.edu.co

Lucy Erazo-Coronado, Universidad Libre, Colombia

Profesor Universidad Metropolitana / Universidad Libre, Barranquilla (Colombia). https://orcid.org/0000-0002-5170-7263. lerazoc@unimetro.edu.co

Ana María Erazo Coronado, Universidad Metropolitana, Colombia

Profesor titular, Universidad Metropolitana, Barranquilla (Colombia).
https://orcid.org/0000-0002-6696-4107. aerazo@unimetro.edu.co

Miurika Ramos-Llanes, Universidad Metropolitana, Colombia

Especialización en Periodoncia, Universidad Metropolitana, Barranquilla (Colombia). https://orcid.org/0000-0003-1462-3017. miurikaramos@gmail.com

Diana Contreras-Nieto, Universidad Metropolitana, Colombia

Especialización en Periodoncia, Universidad Metropolitana, Barranquilla (Colombia). https://orcid.org/0000-0002-0005-6210. dianarcontrerasn@hotmail.com

Published

2024-02-29

How to Cite

Rebolledo-Cobos, M. L. ., Viaña Bermúdez, F., Erazo-Coronado, L., Erazo Coronado, A. M., Ramos-Llanes, M. ., & Contreras-Nieto, D. (2024). Relationship of herpes simplex virus and stage IV periodontitis: A systematic review of the literature. Salud Uninorte, 40(1), 200–215. https://doi.org/10.14482/sun.40.01.620.112

Issue

Section

Revisión Sistemática

Most read articles by the same author(s)