Endogenous hypercortisolism: A case report about an ACTH-producing pituitary adenoma Cushing disease

Authors

  • Luis Rodríguez Arrieta Universidad de Antioquia, Colombia
  • Dolcey Márquez Florián Universidad del Norte, Colombia
  • Ana Mejía Sanjuanelo Universidad del Norte, Colombia
  • Mariana Pérez de la Torre Universidad del Norte, Colombia
  • Valeria Márquez Gallego Universidad del Norte, Colombia

DOI:

https://doi.org/10.14482/sun.41.01.999.563

Keywords:

Key words: cushing, hypercortisolism, pituitary, case, report, cushing, hypercortisolism, pituitary, case report, case, report

Abstract

Introduction: Cushing syndrome is a rare endocrine pathology characterized by signs and symptoms secondary to an excessive increase in serum glucocorticoid levels Endogenous hypercortisolism originates from a pituitary adenoma that produces adrenocorticotropic hormone (ATCH) that is denominated Cushing disease (CD). This form of the disease represents approximately 65-70% of cases of endogenous Cushing syndrome, and it has a higher incidence in women between 25-45 years old (1).  

Objective: This clinical case presentation aims to provide knowledge for identifying and approaching endogenous hypercortisolism secondary to ACTH-producing pituitary adenoma. 

Case presentation: The following is a clinical case compatible with Cushing disease with tests that confirm the excess of the function of the ACTH-Cortisol axis and the location of the lesion through the Sella turcica contrast MRI. Subsequently, associated pathologies were controlled and treated with the removal of pituitary adenoma by endoscopic skull base. 

Discussion and conclusion: It is important to identify the clinical manifestations of Cushing disease timely, have a rigorous diagnostic boarding, and define the interventions to control hypercortisolism to avoid future complications. 

Author Biographies

Luis Rodríguez Arrieta, Universidad de Antioquia, Colombia

 Endocrinólogo, departamento Endocrinología y Medicina Interna, Universidad de Antioquia. drluisrodrigueza@gmail.com. https://orcid.org/0000-0001-9360-4943 

Dolcey Márquez Florián, Universidad del Norte, Colombia

Radiólogo, Universidad del Norte. Profesor y coordinador, Departamento de Radiología e Imágenes Diagnósticas, Universidad del Norte. dolceym@gmail.com. https://orcid.org/0009-0002-7261-9745 

Ana Mejía Sanjuanelo, Universidad del Norte, Colombia

Medicina interna, Universidad del Norte. anammejia629@gmail.com.  https://orcid.org/0000-0001-9499-8649  

Mariana Pérez de la Torre, Universidad del Norte, Colombia

Residente Medicina Interna, Universidad del Norte. marianadelatorre94@gmail.com. https://orcid.org/0009-0003-0381-6208 

Valeria Márquez Gallego, Universidad del Norte, Colombia

 Medicina general, Universidad del Norte. Internado rotatorio, Hospital Universidad del Norte. valerimg@gmail.com. https://orcid.org/0009-0007-3314-7016 

Published

2025-04-01

How to Cite

Rodríguez Arrieta, L., Márquez Florián, D. ., Mejía Sanjuanelo, A. ., Pérez de la Torre, M. ., & Márquez Gallego, V. (2025). Endogenous hypercortisolism: A case report about an ACTH-producing pituitary adenoma Cushing disease . Salud Uninorte, 41(1), 420–431. https://doi.org/10.14482/sun.41.01.999.563

Issue

Section

Clinic Case

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