Intraventricular hemorrhage and factors associated in preterm newborns

Authors

  • Isabel Cristina Sánchez Escobar niversidad Pontificia Bolivariana, Colombia
  • Juan Nicolas Sarmiento Naranjo Universidad Pontificia Bolivariana, Colombia
  • María José Marín Castro Universidad Pontificia Bolivariana, Colombia
  • María Alejandra Palacio Velásquez Universidad Pontificia Bolivariana, Colombia
  • Juan Pablo Orozco Forero Universidad Pontificia Bolivariana, Colombia
  • Libia María Rodríguez Padilla Universidad Pontificia Bolivariana, Colombia

DOI:

https://doi.org/10.14482/sun.40.01.357.159

Keywords:

Infant, Premature, Cerebral Intraventricular Hemorrhage, Infant, Very Low Birth Weight, Risk Factors

Abstract

Objective: Estimate the frequency of intraventricular hemorrhage and associated factors in hospitalized preterm infants in a highly complex neonatal intensive care unit. 

Methodology: Cohort study, which included neonates younger than 37 weeks gestation, attended in a highly complex institution, between January 2015 and December 2018; The development of intraventricular hemorrhage diagnosed by imaging methods was assessed. The data was obtained from the review of the electronic medical records and sociodemographic and clinical variables were analyzed. 

Results: 296 patients were included, 128 (43.2 %) were women; 23 patients (7.8 %) developed intraventricular hemorrhage, which predominated in the female sex (11.7 %). The median gestational age was 34 weeks. The factors associated with the development of intraventricular hemorrhage were birth weight below 1500 gr, infections (p <0.0001), apnea symptoms (<0.0001), hyperglycemia (p = 0.025) and surfactant requirement (p = 0.019); meanwhile, prenatal steroids behaved as a protective factor (p = 0.002). Patients with intraventricular hemorrhage had a greater need for mechanical ventilation, use of inotropics or vasopressors, more transfusions, and a longer hospital stay. 

?Conclusions: Despite the fact that intraventricular hemorrhage turned out to be a rare pathology in the analyzed neonatal population, there are risk factors related to its development, such as gestational age, low birth weight, infections, apneas, and hyperglycemia. 

Author Biographies

Isabel Cristina Sánchez Escobar, niversidad Pontificia Bolivariana, Colombia

Especialista en Pediatría, Universidad Pontificia Bolivariana, Medellín (Colombia).
orcid.org/0000-0002-4980-892x. https://scienti.minciencias.gov.co/cvlac/
visualizador/generarCurriculoCv.do?cod_rh=0001652965. isabel.sanchez@upb.edu.co

Juan Nicolas Sarmiento Naranjo, Universidad Pontificia Bolivariana, Colombia

Estudiante de Medicina, miembro Semillero de Investigación (SIFAM), Universidad
Pontificia Bolivariana, Medellín (Colombia). https://orcid.org/0009-0008-4317-1447 
https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.
do?cod_rh=0002076454. juan.sarmiento@upb.edu.co

María José Marín Castro, Universidad Pontificia Bolivariana, Colombia

Estudiante de Medicina, miembro Semillero de Investigación (SIFAM), Universidad
Pontificia Bolivariana, Medellín (Colombia). https://orcid.org/0000-0003-1060-365X 
https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.
do?cod_rh=0000149391. maria.marinc@upb.edu.co

María Alejandra Palacio Velásquez, Universidad Pontificia Bolivariana, Colombia

Estudiante de Medicina, miembro Semillero de Investigación (SIFAM), Universidad
Pontificia Bolivariana, Medellín (Colombia). https://orcid.org/0000-0001-5634-4986  https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.
do?cod_rh=0001789962.  maria.palaciov@upb.edu.co 

Juan Pablo Orozco Forero, Universidad Pontificia Bolivariana, Colombia

Especialista en Pediatría. Docente Facultad de Medicina, Universidad Pontificia Bolivariana,
Medellín (Colombia). https://orcid.org/0000-0002-4166-4773 https://scienti.minciencias.gov.co/cvlac/
visualizador/generarCurriculoCv.do?cod_rh=0001665873. juanp.orozcof@upb.edu.co

Libia María Rodríguez Padilla, Universidad Pontificia Bolivariana, Colombia

MSc en Epidemiología. Docente Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín
(Colombia). https://orcid.org/0000-0001-7294-3735  https://scienti.minciencias.gov.co/cvlac/
visualizador/generarCurriculoCv.do?cod_rh=0000043648. libia.rodriguez@upb.edu.co

Published

2024-02-29

How to Cite

Sánchez Escobar, I. C., Sarmiento Naranjo, J. N., Marín Castro, M. J. ., Palacio Velásquez, M. A., Orozco Forero, J. P. ., & Rodríguez Padilla, L. M. (2024). Intraventricular hemorrhage and factors associated in preterm newborns. Salud Uninorte, 40(1), 109–126. https://doi.org/10.14482/sun.40.01.357.159

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Section

Original Article

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